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NRTIs’ effect on the sequence of mitochondrial DNA HV 2 in HIV infected patients
Ya-Song WU MD, PhD, Xin-Yue CHEN MD, Ying SHI PhD, Hao WU MD, De-Xi CHEN MD, PhD, Yu SUN MD, Fu-Jie ZHANG MD,
《医学前沿(英文)》 2010年 第4卷 第2期 页码 177-184 doi: 10.1007/s11684-010-0038-1
关键词: nucleoside reverse transcriptase inhibitors human immunodeficiency virus mitochondrial DNA D loop mutation
Atomistic characterization of binding modes and affinity of peptide inhibitors to amyloid-
Fufeng LIU,Wenjie DU,Yan SUN,Jie ZHENG,Xiaoyan DONG
《化学科学与工程前沿(英文)》 2014年 第8卷 第4期 页码 433-444 doi: 10.1007/s11705-014-1454-6
关键词: Alzheimer’s disease amyloid β-protein peptide inhibitors protein-protein interaction molecular dynamics simulation
Abbas TEIMOURI, Nasrin SOLTANI, Alireza Najafi CHERMAHINI
《化学科学与工程前沿(英文)》 2011年 第5卷 第1期 页码 43-50 doi: 10.1007/s11705-010-0532-7
关键词: corrosion inhibitors mild steel acidic medium theoretical studies DFT
Highly hydrophobic oil−water separation membrane: reutilization of waste reverse osmosis membrane
《化学科学与工程前沿(英文)》 2023年 第17卷 第10期 页码 1606-1615 doi: 10.1007/s11705-022-2200-0
关键词: oil–water separation wasted reverse osmosis membrane hydrophobic modification
Mitogen-activated protein kinase pathway inhibitors: inhibitors for diseases?
Xu WANG MS, Xiao-Wei GONG MD, PhD, Yong JIANG MD, PhD, Yu-Hua LI PhD,
《医学前沿(英文)》 2010年 第4卷 第1期 页码 46-53 doi: 10.1007/s11684-010-0010-0
关键词: mitogen-activated protein kinase drug target inhibitor signal transduction disease
Zhen Xiang, Yingyan Yu
《医学前沿(英文)》 2019年 第13卷 第1期 页码 24-31 doi: 10.1007/s11684-019-0679-7
关键词: immune checkpoint blockade sensitivity resistance data mining
Analysis of interactions of immune checkpoint inhibitors with antibiotics in cancer therapy
《医学前沿(英文)》 2022年 第16卷 第3期 页码 307-321 doi: 10.1007/s11684-022-0927-0
关键词: tumor immunotherapy immune checkpoint inhibitor antibiotics gut microbiota drug–drug interaction
Centrifuge experiments for shallow tunnels at active reverse fault intersection
Mehdi SABAGH, Abbas GHALANDARZADEH
《结构与土木工程前沿(英文)》 2020年 第14卷 第3期 页码 731-745 doi: 10.1007/s11709-020-0614-7
关键词: reverse fault rupture continuous tunnel geotechnical centrifuge ground surface deformations fragility curves
Advances in newly developing therapy for chronic hepatitis C virus infection
null
《医学前沿(英文)》 2014年 第8卷 第2期 页码 166-174 doi: 10.1007/s11684-014-0334-2
Chronic hepatitis C virus (HCV) infection afflicts a reported 170 million people worldwide and is often complicated by cirrhosis and hepatocellular carcinoma. Morbidity and mortality are decreased with the successful treatment of chronic HCV infection. Increased understanding of the HCV has allowed further development of new direct-acting antiviral (DAA) agents against the HCV and has also allowed the development of IFN-free oral treatment regimens. In late 2013 the first nucleotide polymerase inhibitor regimen with RBV alone for genotypes 2/3 and in combination with a 12-week regimen of PEG-IFN+RBV for genotypes 1, 4 was approved for use in the US. A number of promising new DAA regimens which are IFN-free are in phase 3 development and the first will likely be approved for use in the US in 2014. The currently approved regimens are discussed in detail and currently available data on future regimens are reviewed herein.
关键词: direct-acting antiviral (DAA) nucleotide polymerase inhibitors protease inhibitors
《化学科学与工程前沿(英文)》 2023年 第17卷 第9期 页码 1183-1195 doi: 10.1007/s11705-022-2287-3
关键词: reverse osmosis nanocontainer self-healing chlorine resistance water permeability
《农业科学与工程前沿(英文)》 2022年 第9卷 第1期 页码 133-145 doi: 10.15302/J-FASE-2021401
p-Hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27, HPPD) belongs to the family of Fe(II)-dependent non-heme oxygenases that occur in the majority of aerobic organisms. HPPD has proved to be a promising target in herbicide research and development. A battery of novel triketone-quinoxaline compounds has been designed using a structure-based drug design strategy and then prepared. Enzyme inhibition assays show that these synthesized derivatives possess favorable inhibition capability against Arabidopsis thaliana HPPD with IC50 values ranging from 0.317 to 0.891 μmol·L−1. Subsequently, the molecular docking results indicate that two adjacent carbonyls of the triketone moiety of the representative compound 2-(2,3-dimethyl-8-(o-tolyl)quinoxaline-6-carbonyl)-3-hydroxycyclohex-2-en-1-one (7d) engage in chelation with the ferrous ion of A. thaliana HPPD in a bidentate pose, and its quinoxaline scaffold forms two sets of parallel π-stacking interaction between two phenylalanine residues (Phe424 and Phe381). In addition, the extended phenyl group also interacts with Phe392 in a π-π stacking way. This study indicates that triketone-quinoxaline is a promising scaffold for discovering HPPD inhibitors with substantially increased potency, providing insight into the molecular design of new herbicides.
《化学科学与工程前沿(英文)》 2023年 第17卷 第3期 页码 347-357 doi: 10.1007/s11705-022-2246-z
关键词: reverse separation graphene membrane ethanol/water separation molecular simulation
《环境科学与工程前沿(英文)》 2022年 第16卷 第4期 doi: 10.1007/s11783-021-1480-9
• RED performance and stack resistance were studied by EIS and LSV.
关键词: Reverse electrodialysis Electrochemical impedance spectroscopy Concentration polarization Spacer shadow effect
Preparation of reverse osmosis membrane with high permselectivity and anti-biofouling properties for
《环境科学与工程前沿(英文)》 2022年 第16卷 第7期 doi: 10.1007/s11783-021-1497-0
• Nanoparticle incorporation and anti-biofouling grafting were integrated.
关键词: Anti-biofouling grafting Nanoparticle incorporation Sterilization rates Water flux Water flux recovery
《环境科学与工程前沿(英文)》 2023年 第17卷 第9期 doi: 10.1007/s11783-023-1708-y
● Appreciable H2O2 production rate was achieved in MRCs utilizing NH4HCO3 solutions.
关键词: Microbial reverse-electrodialysis cell Hydrogen peroxide production Ammonium bicarbonate Electrolysis cell Optimization
标题 作者 时间 类型 操作
NRTIs’ effect on the sequence of mitochondrial DNA HV 2 in HIV infected patients
Ya-Song WU MD, PhD, Xin-Yue CHEN MD, Ying SHI PhD, Hao WU MD, De-Xi CHEN MD, PhD, Yu SUN MD, Fu-Jie ZHANG MD,
期刊论文
Atomistic characterization of binding modes and affinity of peptide inhibitors to amyloid-
Fufeng LIU,Wenjie DU,Yan SUN,Jie ZHENG,Xiaoyan DONG
期刊论文
Synthesis of mono and bis-4-methylpiperidiniummethyl-urea as corrosion inhibitors for steel in acidic
Abbas TEIMOURI, Nasrin SOLTANI, Alireza Najafi CHERMAHINI
期刊论文
Highly hydrophobic oil−water separation membrane: reutilization of waste reverse osmosis membrane
期刊论文
Mitogen-activated protein kinase pathway inhibitors: inhibitors for diseases?
Xu WANG MS, Xiao-Wei GONG MD, PhD, Yong JIANG MD, PhD, Yu-Hua LI PhD,
期刊论文
Screening responsive or resistant biomarkers of immune checkpoint inhibitors based on online databases
Zhen Xiang, Yingyan Yu
期刊论文
Centrifuge experiments for shallow tunnels at active reverse fault intersection
Mehdi SABAGH, Abbas GHALANDARZADEH
期刊论文
Self-healing polyamide reverse osmosis membranes with temperature-responsive intelligent nanocontainers
期刊论文
DISCOVERY OF TRIKETONE-QUINOXALINE HYBRIDS AS POTENT HPPD INHIBITORS USING STRUCTURE-BASED DRUG DESIGN
期刊论文
Mechanism of ethanol/water reverse separation through a functional graphene membrane: a molecular simulation
期刊论文
Tracing the impact of stack configuration on interface resistances in reverse electrodialysis by in situ
期刊论文
Preparation of reverse osmosis membrane with high permselectivity and anti-biofouling properties for
期刊论文